Faculty Research

Title

Specifically Targeting the CD22 Receptor of Human B-cell Lymphomas with RNA Damaging Agents

Document Type

Article

Publication Date

2001

Abstract

Targeting CD22 on human B-cells with a monoclonal antibody conjugated to a cytotoxic RNAse causes potent and specific killing of the lymphoma cells in vitro. This translates to anti-tumor effects in human lymphoma models in SCID mice. RNA damage caused by RNAses could be an important alternative to standard DNA damaging chemotherapeutics. Moreover, targeted RNAses may overcome problems of toxicity and immunogenicity associated with plant or bacterial toxin containing immunotoxins.

Comments

Publication Information.

Newton, D. L., Hansen, H. J., Liu, H., Ruby, D., Iordanov, M. S., Magun, B. E., Goldenberg, D. M., & Rybak, S. M. (2001). Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents. Critical Reviews in Oncology/Hematology, 39(1-2), 79-86. doi:10.1016/S1040-8428(01)00116-0

First Page

79

Last Page

86

DOI

10.1016/S1040-8428(01)00116-0