Specifically Targeting the CD22 Receptor of Human B-cell Lymphomas with RNA Damaging Agents
Targeting CD22 on human B-cells with a monoclonal antibody conjugated to a cytotoxic RNAse causes potent and specific killing of the lymphoma cells in vitro. This translates to anti-tumor effects in human lymphoma models in SCID mice. RNA damage caused by RNAses could be an important alternative to standard DNA damaging chemotherapeutics. Moreover, targeted RNAses may overcome problems of toxicity and immunogenicity associated with plant or bacterial toxin containing immunotoxins.
Newton, Dianne L.; Hansen, Hans J.; Liu, Huaitian; Ruby, Dale; Iordanov, Mihail S.; Magun, Bruce E.; Goldenberg, David M.; and Rybak, Susanna M., "Specifically Targeting the CD22 Receptor of Human B-cell Lymphomas with RNA Damaging Agents" (2001). Faculty Research. 16.